CIP & SIP Simulation Process for Tube Filling Machines
57%
Reduced Cycle Time
100%
Throughput Increased
BACKGROUND
A pharmaceutical company required an automated CIP and SIP solution for their tube filling machine to ensure product quality, operator safety and compliance with cGMP standards.
CHALLENGE
- Ensuring hygienic, safe, and compliant production
- Product changeovers causing cross-contamination risk
- Manual cleaning that is time-consuming and inconsistent
- Need for validated cleaning and sterilization per cGMP
- Requirement to reduce downtime and increase productivity
APPROACH
CIP PROCESS FLOW
Pre rinse (RO Water) > Alkaline wash (1-2%) 70-75°C > Intermediate rinse (RO Water) > Acid wash > Final rinse
SIP PROCESS FLOW
Pre rinse > Steam heating > SIP with pure steam > 121-124°C(20-30 min) > Sterile air/ steam trap >
Sterile condition ready for production